Cryoprecipitate: Bacterial contamination

Note: A photo of cryoprecipitate with bacterial contamination is not available. If you see a component with an unusual or atypical appearance, please take a photo (higher resolution is preferred) and share it with us so it may be considered for inclusion in the Visual Inspection Tool. Photos will be credited and only used with permission. 

Bacterial contamination is the presence of bacteria in the blood. Blood should be free of bacteria. Blood is collected and processed under sterile conditions to maintain this aseptic state. Bacterially contaminated cryoprecipitate should NOT be transfused and any components suspected of bacterial contamination based on a visual inspection should be reported to Canadian Blood Services using the feedback form on blood.ca. Contact the nearest distribution centre to report potential contamination and receive further instructions.

Bacterial contamination may be related to the donor or subsequent manufacturing processes. 

• Donor with asymptomatic bacteremia (i.e., bacteria in blood)  
• Inadequate cleansing of skin prior to venipuncture. To minimize bacterial contamination, Canadian Blood Services uses a diversion pouch for the first portion of the blood collection. This captures the skin plug and skin bacteria and prevents them from entering the main unit.  
• Loss of sterility during component manufacturing or handling. 

Visual appearance 

• The presence of bacteria may produce gas resulting in unusual air bubbles. 
• The presence of bacteria may activate clotting resulting in clots and fibrin strands. 
• Cloudiness