Transfusion medicine

Recent Updates

Modified on:

Feb 14, 2019

Transfusion-related acute lung injury (TRALI)

Transfusion-related acute lung injury (TRALI) is a rare but serious syndrome characterized by sudden acute respiratory distress following transfusion. It is defined as new, acute lung injury (ALI) during or within six hours after blood product administration in the absence of temporally-associated risk factors for ALI. All plasma-containing blood products have been implicated in TRALI, including rare reports with IVIg and cryoprecipitate.

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Published:

Aug 10, 2018

Immune Globulin Products

Chapter 4

Immune globulin (Ig) products are generated from plasma collected from a large number of carefully screened donors. Ig products may be used as replacement therapy for immunodeficiency patients or as immunomodulatory therapy for autoimmune and alloimmune disorders. Ig products include intravenous Ig (IVIg), subcutaneous Ig (SCIg), RhD Ig (RhIg) and hyperimmune globulins.

Modified on:

Feb 11, 2019

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Platelet product quality remains high after seven days of storage

In August 2017, Canadian Blood Services changed its platelet product testing procedure to improve the detection of bacterial contamination. This change enhanced the safety of Canadian Blood Services platelet products and provided the opportunity to improve inventory management by extending the platelet shelf life from five to seven days.

Upcoming Events

Topic Teaching: Edmonton Autologous Stem Cell Manufacturing Program

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When

February 19, 2019 | 12:00PM to 1:00PM

Where

Toronto/Webinar

Presented by:

Dr. Jelena Holovati
Director, Edmonton Stem Cell Manufacturing Program
Canadian Blood Services

Objectives:

1. To understand the key steps in autologous stem cell manufacturing process.
2. To highlight recent process improvement activities in Edmonton HSC manufacturing facility.

References:

n/a

U of T Rounds: Blood Product Provision for Rural and Indigenous Patients

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When

February 28, 2019 | 12:00PM to 1:00PM

Where

Toronto/Webinar

Presented by:

Jacob Pendergrast, MD, FRCPC
Assistant Professor, University of Toronto
University Health Network Blood Transfusion Service

Learning Objectives:

1. To discuss the current health status of Canadian rural and Indigenous populations.
2. To review the history of health care provision to these populations.
3. To explore the challenges and opportunities for provision of safe transfusion support to these areas.

Journal Club

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When

March 12, 2019 | 12:00PM to 1:00PM

Where

Toronto/Webinar

Speaker:

Valerie Arsenault

More details to follow.

Blog

Modified on:

Feb 13, 2019

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New way to check the quality of blood before opening the bag

As part of a larger ongoing effort to develop non-invasive technologies to monitor blood products during storage, researchers have developed a new technique to assess the quality of blood without breaching the sterility of blood bags.

Modified on:

Feb 7, 2019

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Stories worth Sharing: Highlights from our partners: Thrombomodulin: Old protein with new functions and hope

This week, we highlight work from one of our partners, the Centre for Blood Research. Wayne Zhao describes a review by Dr. Ed Conway, Centre for Blood Research director and adjunct scientist at the Centre for Innovation. This review describes the many roles of thrombomodulin, a protein involved in blood coagulation.

Modified on:

Jan 23, 2019

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Research Unit: What's in a bag of plasma?

In this study, Dr. William Sheffield and Craig Jenkins from the Centre for Innovation tested levels and activities of important plasma factors for coagulation in recovered plasma. They found that the way in which plasma is manufactured from whole blood impacts the composition of recovered plasma.