LearnTransfusion Series

Topic Teaching: Regulation of Vascular Stability in Traumatic Injury by Novel Blood Products and Cellular Therapies

29 janvier, 2019 | 12:00 - 13:00 (EDT)


Presented by

Dr. Shibani Pati
Associate Professor
Univerity of California San Francisco
Laboratory Medicine


1.  To understand critical issues, clinical and pathophysiological, in trauma patients.
2.  To understand the scope for utilizing novel blood products in trauma and critical care applications.
3.  To understand the therapeutic potential of cellular therapies in mitigating outcome in trauma.


1.    Cellular therapies in trauma and critical care medicine: Looking towards the future.  Pati S, Rasmussen TE.  PLoS Med. 2017 Jul 11;14(7):e1002343. doi: 10.1371/journal.pmed.1002343. eCollection 2017 Jul.  PMID:  28700606
2.    Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers.  Pati S, Pilia M, Grimsley JM, Karanikas AT, Oyeniyi B, Holcomb JB, Cap AP, Rasmussen TE.  Shock. 2015 Dec;44(6):505-23. doi: 10.1097/SHK.0000000000000482. Review.  PMID:  26428845
3.    Plasma Transfusion: History, Current Realities, and Novel Improvements.  Watson JJ, Pati S, Schreiber MA.  Shock. 2016 Nov;46(5):468-479. Review.  PMID:  27380536
4.    Lyophilized plasma attenuates vascular permeability, inflammation and lung injury in hemorrhagic shock.  Pati S, Peng Z, Wataha K, Miyazawa B, Potter DR, Kozar RA.  PLoS One. 2018 Feb 2;13(2):e0192363. doi: 10.1371/journal.pone.0192363. eCollection 2018.  PMID:  29394283
5.    Resuscitation of Hypotensive Traumatic Brain Injured Animals With Spray-Dried Plasma Does Not Adversely Alter Physiology and Improves Blood-Brain Barrier Function.  McDaniel S, Golla S, Moore AN, DaCorta J, Bode A, Pati S, Dash PK, Zhao J.  Mil Med. 2017 Jul;182(7):e1706-e1711. doi: 10.7205/MILMED-D-16-00185.  PMID:  28810961
6.    Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis.  Chang R, Holcomb JB, Johansson PI, Pati S, Schreiber MA, Wade CE.  Shock. 2018 Jan;49(1):53-61. doi: 10.1097/SHK.0000000000000918.  PMID:  28591008
7.    Serum from dengue virus-infected patients with and without plasma leakage differentially affects endothelial cells barrier function in vitro.  Tramontini Gomes de Sousa Cardozo F, Baimukanova G, Lanteri MC, Keating SM, Moraes Ferreira F, Heitman J, Pannuti CS, Pati S, Romano CM, Cerdeira Sabino E.  PLoS One. 2017 Jun 6;12(6):e0178820. doi: 10.1371/journal.pone.0178820. eCollection 2017.  PMID:  28586397
8.    Dried plasma: state of the science and recent developments.  Pusateri AE, Given MB, Schreiber MA, Spinella PC, Pati S, Kozar RA, Khan A, Dacorta JA, Kupferer KR, Prat N, Pidcoke HF, Macdonald VW, Malloy WW, Sailliol A, Cap AP.  Transfusion. 2016 Apr;56 Suppl 2:S128-39. doi: 10.1111/trf.13580. Review.  PMID:  27100749
9.    Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets.  Baimukanova G, Miyazawa B, Potter DR, Muench MO, Bruhn R, Gibb SL, Spinella PC, Cap AP, Cohen MJ, Pati S.  Transfusion. 2016 Mar;56 Suppl 1:S65-75. doi: 10.1111/trf.13532.  PMID:  27001364
10.  Modulating the endotheliopathy of trauma: Factor concentrate versus fresh frozen plasma.  Pati S, Potter DR, Baimukanova G, Farrel DH, Holcomb JB, Schreiber MA.  J Trauma Acute Care Surg. 2016 Apr;80(4):576-84; discussion 584-5. doi: 10.1097/TA.0000000000000961.  PMID:  26808040


Note:  The session is a self-approved group learning activity (Section 1) as defined by the Maintenance of Certification program of The Royal College of Physicians and Surgeons of Canada.

To register for the LearnTransfusion series, send an email to learn.transfusion@blood.ca with  “Weekly Transfusion Medicine Seminars” in the subject line. Include your name and complete e-mail address in the body of the e-mail, and confirm that you would like to register for the LearnTransfusion series. You will then receive weekly email notifications of upcoming series events with details on how to join the webinars (e.g., call-in number and a link to register for the webinar).

The LearnTransfusion series is the seminar component of the Areas of Focused Competency (AFC)-Diploma Program in Transfusion Medicine. The series, organized by Canadian Blood Services is also open to all practitioners in the field of Transfusion Medicine. Through a series of regular webinars, trainees and practitioners are exposed to various scientific, technical and clinical aspects of transfusion medicine.