Immunohematology boot camp: Duffy

This program will describe the structure, distribution, and clinical significance of the Duffy Blood Group System. Antibodies to Duffy antigens are usually clinically significant and have been reported to cause hemolytic disease of the fetus and newborn. The FY glycoprotein, atypical chemokine receptor 1 ACKR1 will be explored and altered expressions of the alleles will be defined. Case studies will demonstrate how antibodies in this blood group may be detected in the blood bank.

Presented by

Jayanna Slayten MS, MT(ASCP) SBB^cm
Supervisor, IUH Blood Bank, Indiana University Health, Indianapolis, IN
Adjunct Faculty, University of Texas Medical Branch, Galveston, TX

Learning objectives

After participating in this educational activity, participants should be able to:

1. Describe the clinical significance of antibody formation to the Duffy antigens in clinical practice.
2. Explain the significance of the GATA promoter region mutation as it relates to individuals who appear Fy(a-b-).
3. Highlight the role of the Duffy glycoprotein in malarial infections.
4. Explore the functional aspects of the FY Glycoprotein, ACKR1.
5. Apply the known serologic characteristics of the antibodies in the Duffy system to resolve complex serologic case studies.

Registration

Registration includes access to both the live and on-demand version of this eCast. Registration for the live eCast will close 1 hour prior to the eCast start time. If you register after this time you will receive access to the on-demand eCast when it is available.

For additional information and to register, visit the AABB event webpage. Please note: Registration fees are required for AABB events.