The Centre for Blood Research

Seminar series: Innate immunity in the brain: induction of the inflammasome-pyroptosis axis (IPA) by neurotropic viruses


Event details

This lecture is part of the CBR lecture series. Held on Wednesdays from 1-2pm PT, CBR seminars feature insightful scientific talks, with speakers from a range of clinical, industry and academic backgrounds.

The inflammasome-pyroptosis axis (IPA) coordinates an inflammatory type of regulated lytic cell death that is underpinned by caspase-activated poreforming gasdermin proteins. HIV, monkeypox virus, and SARS-CoV-2 trigger activation of caspases-1 and -3, which result in neural cell type-specific gasdermin activation with subsequent pyroptosis. These findings demonstrate novel mechanisms by which viral infections cause activation of distinct innate immune pathways and brain disease, while also offering new diagnostic and therapeutic strategies.

Presented by

Dr. Chris Power
Professor, Neurology/Medicine, University of Alberta
Attending Neurologist, Kaye Edmonton Clinic/University of Alberta Hospital


For information about CBR Seminar series events, visit the CBR website: CBR Seminars | Centre for Blood Research ( To receive Zoom access details for CBR Seminar series events, contact Kaitlyn Chuong (