Seminar Series: Endothelial caveolae, nitric oxide and cholesterol in vascular diseases and muscular dystrophy - from bench to bedside

This lecture is part of the CBR seminar series.

The vascular endothelium is a critical and dynamic barrier between the blood and underlying tissues. We study how changes in endothelial function, vascular sheer stress and nitric oxide (NO) release can prevent atherosclerosis, aortopathies and thrombosis using transgenic animals and novel small molecules. Through proteomic analyses of endothelial caveolae and lipid rafts, we document how changes in vascular homeostasis and circulating lipoproteins exacerbate muscular dystrophy (MD) and muscle cholesterol synthesis. How our work has impacted patient care is discussed.

Presented by

Dr. Pascal Bernatchez
Associate Professor, Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, UBC
Fellow, American Heart Association (FAHA)

Registration

For information about CBR Seminar series events, visit the CBR website: CBR Seminars | Centre for Blood Research (ubc.ca). To receive Zoom access details for CBR Seminar series events, contact Kaitlyn Chuong (kaitlyn.chuong@ubc.ca).